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Infectious virusand total virus load

Feb 16, 2003

Dear Dr Holodniy,

You stated in an answer poster April 11, 2001, that "Infectious virus is a much smaller fraction of total viral load."

Could you please expain the difference between "infectious virus" and "total virus load" in this context?

Yours sincerely


Response from Dr. Holodniy

Cells that are infected with HIV produce lots of virus. Many of these viral particles are not infectious. This has been measured indirectly by measuring the amount of viral particles by viral load (HIV RNA levels) versus the viral infectious titer, a calculation of the amount of particles in a volume of cells or cell free plasma/fluid that can infect a certain number of t cells.

what is cell-free?
Clarification on P24 Antigen test etc

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