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PCR HCV negative?

Dec 26, 2002

Dear Dr. Mark,

I have one short question. Are patients who had Hepatitis C with PCR HCV RNK negative (after treatment) infectious?

Kind regards, Alexander

Response from Dr. Holodniy

Not clear. Being "PCR negative" means there is no detectable HCV in the blood serum. We know that HCV can exist in blood mononuclear cells, liver and in other organs. Most HCV docs speak of sustained virologic response (SVR) to indicate when people have an undetectable blood plasma viral load at least 6 months after stopping treatment.

is this a bad indicator
CD4 stability ?

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