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Very confused
Sep 15, 2002

Is it true that the Elisa can be positive in the early stages of infection and the western blot be negative? I didn't think the Elisa would be positive before the western blot because I read a response from you stating they usually turn positive around the same time. I thought that if you had true antibodies to the HIV virus that the western blot would pick up on that as well, is that true? I can't see having a true positive Elisa and a negative western blot can you? Please explain. Thank you for your time.

Response from Dr. Holodniy

This is the last word and time on this issue. An HIV ELISA can be positive and a western blot be negative (most likely a false positive ELISA) or indeterminate (early seroconversion or again false positive).



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