|3 years, low VL, stable CD4, high CD8
Sep 8, 2002
I was infected sometime in July 1999. I had a very severe acute viral syndrome. I had just begun the vaxgen vacine trial and received 1 injection prior to the viral syndrome and one after prior to my positive test result, though I do not know wether I received the placebo or the vaccine. My initial CD4 count was 324 and my viral load was 28,000. In Dec. 2000 my CD4 was 342 with VL 5,300. I was quite shocked by the low numbers, but another test about a month later produced similar results. Because of insurance interruptions I had not been seen by a doctor until 2 weeks ago. Those test results came back CD4 344, VL 1876, and CD8 1070. (I don't have CD8 info for the prior tests). What do you make of these results? Is it possible that the vaccine has in some way strenghtened my immune response? Is this test result profile suggest LTNP. And is it possible that my relatively low CD4 is reflective of a naturally low baseline rather than disease progression?
| Response from Dr. Holodniy
It's hard to know whether the vaccine had an effect. The CD4 count is essentially unchanged. Since we don't have CD4 counts in you without infection, it's hard to know what your true baseline CD4 without infection is. The CD8 response is expected just with HIV infection. I am not sure given your recent infection and those numbers that you fit the definitionn of LTNP.
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