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Route of exposure and time to seroconvert
Jul 14, 2002

Dear Mark,

Is there any data or information on how time to seroconvert may depend on the route of exposure? There seems to be a suggestion from laypeople's comments that sexual expousures seroconvert faster than needle/occupational exposures (even when not given PEP which I gather may delay seroconversion). Is there any truth in this or are people saying this on the basis of the much quoted case of the healthcare worker who seroconverted at 9+ months following a needlestick injury? I don't see logically why there should be any difference.

Many thanks for your time and caring.

Response from Dr. Holodniy

Seroconversion is a complicated process and is dependent on the type and amount of virus in the inoculum and the host factors (underlying genetics, genital ulcer disease, underlying illnesses, etc).



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