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3rd and 4th generation test

Feb 18, 2001

You previously mentioned that the different generations of hiv tests differ in types of hiv-1 they detect.Can 3rd or 4th gen. test pick up all the strains we know about(A-h,and O )? What strains would a first generation test detect? Would it matter if the test was a viral load test or an antibody test?

Response from Dr. Holodniy

The generational definition is partially historic. Most testing laboratories are using current generation antibody assays. Some viral load assays have difficulty with some subtypes of HIV-1. But again, these are not approved for diagnosis. MH

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