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What causes for decrease in CD4 and increase in CD8?
Feb 7, 2001

Doctor, I understand that that CD4 levels decrease and CD8 increases as the disease become worse, but I do not understand how these why this ratio is so. What causes for decrease in CD4 and increase in CD8? Can you please help to better understand. Thanks

Response from Dr. Holodniy

The CD4 decrease is a result of HIV infecting and killing those cells. The CD8 increase is an expected reaction to the viral infection itself. MH



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