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Re-infected MDR/Super-infected
Jan 2, 2001

Dear Dr. Mark Holodniy,

If a person were to get hiv infected by someone who either had multiple resistance (say NNRTI and PI resistance) or through "re-infection" would the "newly infected" have ALL resistance and also after reading on the issue -- the multi-resistance strain is less virulent and "kills" cd4 less quickly than wild-type.

If the above is true, why wouldN'T occupational exposures from AIDS patients (who most likely have resistance to multiple regimens -- otherwise they (most likely) would be hiv patients) be infected with "multiple-resistant" hiv strains?

Response from Dr. Holodniy

Not exactly sure what you are asking here. It is true some multi-resistant viruses don't replicate as well as wild type (nonresistant virus). This occurs in the face of ongoing drug pressure. These multi-resistance viruses exist amongst wild type virus. When treatment is stopped, or a these viruses are transmitted to someone else, in the absence of treatment, the virus reverts back to wild type being the predominant strain.

MH



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