CD4 at 450 with 130,000 viral load
Nov 13, 2000
I am a 46 year old gay male and have been HIV positive for over 15 years now. I have not experienced any opportunistic or HIV related infections to date and have been on a 2 different combined drug therapies, most recently, for the past 3 years, Virocep, 3TC and Zeret. It now appears that regimen is no longer working as my viral load continues to advance. My CD4 count, however, remains in the 450 to 500 level with a present viral load of 130,000. My physician has suggested a new drug regimen to include Kaletra. What concerns should I have about starting this new regimen and any specific concerns about my high viral load and early development of resistance to the drug. The reason for my concern is that I understand that, if I develop a resistance to Kaletra that I have pretty much "run the table" so to speak as far as available protease therapies. This part has me somewhat concerned, but after 15 years I guess I should not gripe! Anything you can advise me of would be much appreciated...Thanks much!
Response from Dr. Holodniy
You don't indicate what your first regimen was. If viracept was your first PI, then you should probably have a great response to Kaletra. If you have had 2 different PIs, then a resistance test might be helpful in predicting whether you will have an effective response or not. Make sure your other meds get changed as well, because it's very likely you have 3TC resistance and d4T might also be affected by AZT associated mutations.
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