Effects of mutation on HIV detection.
Nov 27, 2000
The creation of AIDS vaccine is hindered terribly by the rapid mutation of the virus. Does mutation have the same effect on detection methods such as ELISA, Western blot, in situ hybridization methods etc., Could you suggest any specific journals on this subject?. Thank you.
Response from Dr. Holodniy
You are mixing different assays together. ELISA and western blot measure antibodies. Unlikely that mutations would affect detection of these. In situ hybridization measures certain regions of HIV DNA, and could be affected by one or more mutations. You might check on PubMed for more specific questions.
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