Jan 13, 2002
the discovery of dc-sign as the initial connection with hiv gp120 - dc signs are only present on the surface of dendritic cells on mucosal linings. Does this mean that it might be almost physiologically inpossible for hiv to "swim" its way through small cuts or openings on the skin? if there are no dc-signs near the epidermis or dermis, then there would be no blocking mechanism, thus the body's immune system would recognize the virus and kill it before it could enter. what do you think?
Response from Dr. Holodniy
I think we are just beginning to learn about this important receptor on dendritic cells (DC). It facilitates the interaction of CD4 and other coreceptors that are necessary for HIV entry into cells. We don't know if all DC in all tissues have this receptor, or what the density (number)of this receptor on a cell is necessary for appropriate action.
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