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Kaletra and Grapefruit Seed Extract?

Oct 8, 2005

Can I use grapefruit seed extract while using Kaletra? If not, why?

Response from Dr. Holodniy

I would be reluctant to suggest you can use this extract with Kaletra (lopinavir/ritonavir). We know that grapefruit and its juice can inhibit enzymes in the liver that also are involved with Kaletra metabolism.

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