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135t mutation?

Mar 19, 2005

dear doctor I had a virtual phenotype/genotype test done. It showed I was not resistant to any meds.Yet it showed a 135t mutation in nnrti what does that mutation mean? thank you

Response from Dr. Holodniy

The I135T mutation in HIV reverse transcriptase gene is thought by some to result in low level resistance to NNRTIs like nevirapine. It can be seen in some people's virus who have never been on any HIV meds. It is seen somewhat more often in people who have been on NRTIs like AZT. But in those cases where there is significant other mutations to NRTIs but no primary mutations to NNRTIs, currently available data suggests that the 135T does not contribute to NNRTI resistance. Probably more than you wanted to know.

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