Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter 
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Opportunistic InfectionsOpportunistic Infections
         
Rollover images to visit our other forums!
  
  • Email Email
  • Glossary Glossary


PML, HIV-
Aug 16, 2000

Dear Dr. Feinberg, I was reading your response regarding HIV- people with PML. You said it is usually fatal. I have not been able to find any information on the few that do survive PML. My husband was diagnosed with PML after a brain biopsy. He seemed to be improving, but then another MRI showed progression and movement to the other side of the brain. He is being treated with Interferon. How will we know if he is going to survive. If MRI's continue to show progression does that mean he will not survive. He has had this since December. He does not have any other diseases. Thank You

Response from Dr. Feinberg

PML is pretty unusual in HIV- individuals, so I can't point you to a wealth of information about this. The problem is that there are not any specific treatments for it, which is why it usually progresses and is fatal. Interferon is a non-specific treatment which may work in some cases. Cidofovir is a marketed drug for CMV that has activity in the test tube against the virus that causes PML, but it has yet to be proven that it is effective in treating the disease. If there is no MRI or clinical improvement on the interferon, you might want to pursue a trial of cidofovir. Has your husband been evaluated for other causes of immune deficiency besides HIV? Correcting an immune defect if possible may be the most useful approach. I hope your husband has been evaluated by an infectious diseases expert and an immunologist so that you have the most information available on which to base future decisions. Good luck!


Previous
m.chelonae in Aids pt. s/p RIPE
Next
sleep disturbance with joints pain and tiredness

  
  • Email Email
  • Glossary Glossary


 
Advertisement




Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement