|Resistance to Thrush meds
Sep 27, 2000
I have been having problems with my thrush meds, have become resistant to all of them, am taking a study drug, SCH56592, and that one is not doing so well any more. my doctor has suggested that I go on the new study drug ABT. If I do this I have to stop the SCH drug due to interactions, I am afraid that if the ABT doesn't work, I will have the same problem with resistance if I try to go back onto the SCH drug.
Response from Dr. Feinberg
It sounds like you have been taking posaconazole, the investigational drug from Schering. I have had good responses to painting the thrush with a readily available biological dye called 1% gentian violet -- this is done for 3-5 days in a row, and have also had success with oral amphotericin B that is mixed with jello to form a semisolid gel that is easy to swallow.
There are no interaction data that I know of for posaconazole and the new Abbott protease inhibitor, lopinavir/ritonavir, which was just released on the market as Kaletra. Your physician could contact both companies for their best guess -- some azoles, such as fluconazole, have less potential for interactions than others.
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