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microsporidiosis in kidney transplant
Feb 11, 2000

my wife had a kidney transplant in august 1999. developed

a nasty CMV infection that was not resolved by iv ganciclovir. this precipitated a kidney rejection and she was treated with okt3 that really dropped her immune system.

January 2000 she had a disseminated microsporidiosis

w/c lead to nephrectomy of the kt and a diffused pneumonia. was on a ventilator for 12 days..she had just discontinued foscarnet, cytogam, albendazole, fumagillin,

vancomycin, etc. is now on neupogen to boost her neutrophil count. what is her chance of a good recovery.

her microsporidia is of the type E.i septata in her kidney

and E.hellum in her eyes.

Response from Dr. Feinberg

The stronger a person's immune system is, the better the chance that they will get over an OI (or at least, keep it under control). For organ transplant recipients, the weakness in their immune system comes from the drugs they are given to prevent rejection. These medicines can be 'fine-tuned' and increased, decreased or changed, and all of these maneuvers can make her immune system weaker or stronger. If her doctors can successfully manipulate her immune system by just the right amount, she may do OK with the microsporidiosis, but there is no way to know for sure.


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