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Lymphadenopathy
Jun 7, 2001

Hi Doc,

At what stage would someone newly infected with HIV show signs of Chronic Lymphadenopathy (multiple swollen nodes). I have always thought that this would occur during accute infection, but now understand it to be around 8 months after intial infection? Is this correct, and if so, then why does this happen. Is it to do with viral load increasing?

Many thanks.

Response from Dr. Feinberg

Lymph nodes wax and wane throughout the course of HIV disease. They are typically enlarged during acute HIV infection and may increase and decrease in size thereafter. There is no magic 8 month interval associated with this phenomenon. This may be part of the HIV disease activity and can also reflect infections with other organisms. In very advanced disease, lymph nodes tend to be 'burned out' and lose their distinctive architecture.


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