The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Opportunistic InfectionsOpportunistic Infections
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

HIV neg Crypto Meningitis
May 11, 2000

Dear Dr. Feinberg:

I am a gay physician whose partner is 45yo and just developed documented cryptococcal meningitis which responded quickly to Diflucan. He had never been previously ill, was never HIV+ and always practiced safe sex.

He was found to have a CD4 of 99, however HIV antibody testing and viral load testing done two months apart and many months after any possible exposure were negative. Lupus testing and a workup for lymphoma were negative. His past history includes Rocky Mtn Spotted Fever.

My question is: is this bout of crypto an AIDS-related opportunistic infection (in the absence of negative HIV testing)? What other possible etiologies might there be for developing crypto?

Thank you for your response.

Response from Dr. Feinberg

You can be HIV- and develop crypto meningitis if you encounter a heavy inoculum, or if you have some underlying immune deficiency, like lymphoma. Other diseases can change T cell counts and ratios, but the coincidence of all these things happening to the same person raises a red flag. Did he have a direct test for HIV in addition to the standard antibody (ELISA) test? If not, he should have an HIV viral load test Roche Amplicor methodology may result in the fewest false negatives) or a p24 antigen test. I'd suspect HIV until proven otherwise.

need more info on noncompliance

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint