Dec 19, 2000
Very short history description:
Started treatment 87: AZT until 92 aprox. Revisions every three months, only twice had 450 defenses, all the rest + 500/600.
92: started combined with epivir. Always +600/700
Don´t know exactly when started 3 combined treatments, always +600/700/800
Came out viral charge: always active less 6000 generally, and took Sustiva, Crixivan, Ziagen (did not tolerate) but after six months taking any treatment again viral charge + 5000 - 11000, still defenses +800
Tried videx and Hydrea as last resort before going into protease again (DO NOT WANT TO HAVE LIPODISTROPHY), first results 1900 viral charge, 1160 defenses (29%), second results a week ago 800 cd4 (25%) but 31000 viral charge (it scares me - it is the first time).
My question: what should I do?? Should I take a protease inh. although I really don´t want to, but I also don´t want to deteriorate, or could I try Sustiva f.example again for a while although it did not work as I had 5100 viral charge after six months taking it? until other treatments come out?
Thank you for your attention
Response from Dr. Feinberg
My guess is that you're resistant to 3TC (Epivir), AZT and efavirenz (Sustiva), and probably also ddI (Videx). I think your choices now are: one or more protease inhibitors plus d4T (Zerit), or wait until you have some more options, like tenofovir and T-20. Your current T cells and viral load are not that high and you could wait it out without being in immediate danger.
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