Does HIV make one more prone to being allergic to drugs. My daughter has been positive for 7 years and now has a cd4 count of 114. She had surgery a few months ago and has had 3 or 4 infections since then. She was put on an antibiotic and had a severe allergic reaction requiring hospitalization for a day. They gave her a different antibiotic to start the following day and she had another severe allegic reaction requiring emergency treatment (difficulty breathing severe welts, red skin and swelling). They did start her on a third one before being released from the hospital and she did okay. She never had any allergy to anything before this.

It's a good question to which there is not a clear answer. I have taken care of patients who have reactions to many different classes of antibiotics, which is unusual. But there is no mechanism that adequately explains why this would be so at the present time.