Aug 8, 2012
Hi Dr Mac,
I hope all is well with you. One q. Are the new drugs for hcv, boceprivir and incelvik(not sure of the spelling) as effective as hoped when used with interferon and ribavirin? You're the best, Dr Mac. A true healer of body, mind and soul.
Response from Dr. McGovern
Thanks for your question and kind comments!
Boceprevir (Victrelis) and telaprevir (Incivek) are two new protease inhibitors that were approved in the spring of 2011. Both greatly improve treatment cure rates in HCV patients compared to dual therapy alone (eg, Peg Interferon plus ribavirin).
TRiple therapy leads to better cure rates in lots of different patients compared to dual therapy including African Americans, HIV infected patients, patients with cirrhosis...etc...It is a big advance.
However, there are MANY drugs on the way from multiple classes that promise to help improve response rates from about 75% with these regimens to greater than 90% with newer agents. We will know more about the effectiveness and safety of these drugs when we see big treatment trials which are coming soon. And some of these trials will be without interferon...
Exciting days ahead!
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