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Treatment for indian subtype hepatitis c
Dec 22, 2011

Dear Doctor, Which type of hepatitis C is most prevalent in the indian subcontinent? 1 and 3? Are these indian strains susceptible to pegylated interferon, ribavirin, boceprevir and telaprevir? What are the success rates? And what kind of HAART would you recommend for a co-infected person with HIV? What is the longevity of such co0infected patients if on proper treatment and positive lifestyle modification? Best wishes.

Response from Dr. McGovern

In India, genotype 3 and 1 are prevalent...The treatment for G1 is is triple therapy with pegylated interferon, ribavirin, and a protease inhibitor (eg, telaprevir or boceprevir)...The treatment for G3 is dual treatment with pegIFN plus ribavirin....

G3 is relatively easy to treat with great response rates with dual therapy.

Now we see great response rates with G1 as well because of these new HCV protease inhibitors.

As for HIV/HCV....preliminary data with triple therapy looks really promising with great early response rates. We will know in 2012 if the triple therapy leads to viral cure of HCV.



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