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How To Proceed.
Dec 21, 2011

Hello Dr. McGovern, I am a 40 yrs old male who has been living with hepB knowingly for past 10 years and probably for a lot more years unknowingly. I was diagnosed in 2001 with hepB+ and I was also e+. In 2009 my doctor put me on Viread and I turned undetectable in about 3 month and my e+ become e- in at the same time. I have been taking viread ever since and my doctor is suggesting for me to contiue taking viread for a duration of 4years. His reasons are that new studies from europe have shown 10% of patients taking viread may lose surface antigen to the virus. In advice on how to proceed. I am trying to get a Masters in Public Health and I have been admitted to a very good college for it. Do you think is a good idea for me to go for this degree at my age and with HepB? My last lab results were all negative including an MRI of the liver. Thanks.

Response from Dr. McGovern

Your doctor knows you much better than I do. He may want to treat you longer to accomplish something few patients attain - loss of hepatitis B surface antigen, which would be great.

Most patients continue therapy for about a year after seroconversion (defined as when your HBeAg is lost and you gain hepatitis B E antibody).

The benefit of long term therapy in terms of loss of surface antigen only occurs in a small percentage of people. The downside to long-term therapy with Viread is the small risk of renal insufficiency (kidney problems) which usually reverses when the treatment is discontinued.

I would continue more conversation with your doctor, since the answer is not black and white. Hope this helps.



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