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HepB_treatment with pegasys
Aug 2, 2011

Dear Mrs mcGovern0 after 1 year of treatment it seems that i became HBsAg negative. My doctor seems to believe that I may develop antibodies. Is it possible without any new exposure to the virus, the surface antigen to turn positive again ?? If it is to make antibodies, how long could it take ?? (months, years or never?) Thank you for the prompt reply

Response from Dr. McGovern

When people are treated for HBV with pegylated interferon, about 1/3 of them lose their HBe antigen and become HBe antibody positive. They also have no detectable virus in their blood. That is a great response.

However, a very tiny percent (about 2 percent) actually lose their HB surface antigen. That is a great development.

If the HB surface antigen remains nonreactive, yes you may also develop surface antibodies, which is the best response of all. I hope that happens for you.....

viral load increasing from undetectable to 46000 COPIES after Hepatitis B vaccination

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