The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Hepatitis and HIV CoinfectionHepatitis and HIV Coinfection
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Jan 15, 2010

Thank you, Dr. McGovern, for all you do for individuals living with HIV/HCV!

A couple questions about the new HCV protease inhibitor(s):

1) Once Telaprevir is (hopefully) approved, do you believe it will be used in first-line therapy for HCV? Specifically, in genotype 1 treatment-naive patients, will the automatic standard of care become interferon+ribavirin+telaprevir? Or will clinicians continue to use just interferon+ribavirin at first, and reserve the protease inhibitor only for non-responders?

2) I know the percentage of genotype 1 patients who achieve SVR when treated with interferon+ribivirin is about 50% (good, for sure, but not great). How much do you think the addition of Telaprevir to standard therapies could improve the SVR rate among treatment-naive patients with genotype 1 virus? Are there any data addressing this? With Telaprevir, I'm really hoping that the SVR rate for treatment-naive genotype 1 patients will be significantly higher than the current 50% statistic. With the addition of Telaprevir, what percent of this population do you think could potentially achieve SVR (assuming they adhere to treatment)?

Thank you so much!

Response from Dr. McGovern

Excellent question.

Yes, tHese are very exciting times for the treatment of HCV. Although it will be important to wait to hear the full review of all the data by the FDA, the information that have been discussed at major meetings and some of the published articles suggest that triple therapy will become the new standard of care for treatment naive patients with genotype 1 infection. This is due to the better overall responses; furthermore, the use of telaprevir can shorten the duration of treatment to 24 weeks in HCV infected patients.

We will need to await trial information about the use of this drug in HIV/HCV coinfected patients, but I am very hopeful for good outcomes as well since this is a potent therapy with excellent antiviral activity against HCV. Stay tuned.

Confused and Scared
ALL hep tests?

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint