Nov 12, 2009
Well, Dr. have you wever run into this?: I was diagnosed superinfected HIV/HCV/HBV liver biopsy done, stage II all in 6/07 put on Atripla + Ziagen which I never missed a dose .....now new labs came out (HIV ud since shortly after I started ART) My surface antibodies/antigen and core antibodies/antigen all 4 came out NEGATIVE last wk, for HBV, although all 4 were positive in 6/07, 7/08. My HIV specialist says my HepC treatment (interferon + ribavirin) plus Atripla and Ziagen did this. My readings, and my Hepatologist (who presided over my HVC treatment) say that that's impossible, I would always have the core antibodies core and probably the surface too. 2nd battery of tests confirm all HBV negative values AND THE HEPATOLOGIST NOW SAYS I SHOULD GET THE HBV vax "just to be safe" He says he can't explain it 'MAYBE THE PRIOR TESTS WERE WRONG" dOES ANY OF THIS MAKE SENSE??? THANK you
| Response from Dr. McGovern
First of all congratulations on suppression of your HIV and your cure of HCV with interferon/ribavirin....
I agree with your hepatologist that I suspect the first set of labs were probably not yours....I also agree with immunization..However, I would pursue one more test - that of HBV DNA to be certain that you do not have occult infection. There is a paper that describes changing serologies in HIV infected patients with HBV...However, with improvement of your HIV status, I would expect you to gain antibodies - not lose them.
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