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How Long to Treat After Relapse - HBEAG Negative Infection
Sep 18, 2009

Dr. McGovern,

Baraclude treatment right now (HBEAG Negative Infection), six months after treatment achieved negative HBV-DNA test. Doctor said therapy can be stopped after 3 yrs... What if I stopped therapy, then relapse after 3 months, can I start again the therapy? How long to treat this time after having relapse?

Thank you and God Bless...

Response from Dr. McGovern

I am assuming that you started with EAg negative infection. The guidelines do recommend about three years of treatment. However, you are correct to question what you should do if relapse occurs. I personally would follow you very closely to see if that is happening. At the finding of ANY level of viremia (whether low or high) I would restart your therapy right away.

Some have also argued that lifelong therapy may be required. However stay tuned to the latest developments over the years to come, since I am sure we will learn more about who may be at lower or greater risk of relapse based on various markers (such as quantitative HBsAg).

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