More than 1 Genotype?
Aug 7, 2009
I was dx w/ 2b. But I read how the computerized photoscanner that determines genotype just stops when it gets a "predominant genotype" And I read more that about 40% of HCV infected have more than one genotype when a really expensive test is used. So, my question is have there been genotype 2a or 2b people that go through interferon therapy ......and then relapse later but come up w/ genotype 1 or 3? Also my dr. said it was better to have 2b than 2a ..... but when I asked him why, he said people w/ 2a get diabetes more and "other problems" but he couldn't say what the other problems were. Are you aware of certain problems associated w/ specific genotypes ... like more heptocellular cancer, quicker progression to fibrosis, lower life expectancies, worse if you're co-infected w/ HIV, etc. Thankyou. I know these questions are obscure.
Response from Dr. McGovern
I would not pursue further genotype testing. Yes you are correct that the predominant virus is measured, but usually this is all we need on a clinical basis to make treatment decisions.
Genotype 2 is favorable since it responds to treatment so well.
HCV infection in general is associated with an increased risk of diabetes. This risk increases with a family history of diabetes and with excessive weight gain.
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