False Positive Test
Apr 6, 2009
Hello, I would like to know how you can tell if your results are "false positive?" I went to give blood and rec'd a letter that stated the presence of "Hep B Core Antibody."With a Non-Reactive - Anti HCV, HCV NAT, and HbsAg, but a Reactive - HBcAb. So, I followed up with my PCP and he performed a Hep B Virus Profile VI, with results of Negative HBsAg, Hep Be Ag, & Hep Be AB, a positive Hep B Core Ab IgM and Hep B Core Ab, Tot and a Hep B Surface Ab result of 11.56. Of note, I rec'd the Hep B vaccine in 1994. Please render your opinion as my PCP spoke with a Gastro MD and they conclude this could be a "false positive", but how do you know for sure? And is there any benefit to the Hep B Virus DNA, that seems to be so costly? Thanks so much!
Response from Dr. McGovern
If you have surface antibodies to hepatitis B you are protected - whether it was with vaccine (which should be surface antibody alone) versus past exposure (which is identified by core and surface antibodies together).
I would NOT get the HBV DNA test since it would not be expected to be positive if you are protected. Furthermore, your surface antigen is negative and your e antigen is negative. I do NOT expect you to have chronic hepatitis B.
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