|Lamivudine and pegalated interferon for Hep B
Apr 22, 2001
My doctor and I are considering putting me on pegylated interferon and Lamivudine to treat my chronic active/persistent Hep B of eleven years. I just found out this year that I've developed HBeAb. I'm still HBeAg + and my viral load is finally detected. We're aware that pegalated interferon is approved for Hep C only. I would appreciate very much your comment or reference as to where I can find any information (if any now) about whether or not Hep B can be treated with these two drugs and at what dosage of the peg interferon.
| Response from Dr. Dieterich
There is no data yet on that combination for hepatitis B, but it is being studied. The dose of peg interferon alfa 2b is 1.5 mcg/kg just like hep C. It depends on how much HBV DNA you have and what your liver biopsy looks like before I would treat. However in general I think that the combination will be superior to lamivudine monotherapy. Good luck!
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