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CCR5
Apr 21, 2001

I have read a paper that states that individuals with a homozygous 32 base pair deletion in the CCR5 gene are less likely contract AIDS once exposed to HIV. And, people who are heterzygous for the 32 base pair deletion will live longer than people with the wild type CCR5, if they contract HIV. Do the people who are homozygous for the the 32 bp deletion still carry HIV and can they infect others?

Response from Dr. Dieterich

That is true. People who lack the CCR5 receptor cannot contract HIV infection. Therefore they can not pass it on if they do not have it! They are not asymtomatic carrier. The heterozygotes have HIV but usually have a better prognosis, and of course, do carry the virus. DTD



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