Coinfected on interferon & problem with hemolytic anemia
Aug 19, 2008
Help! I am the caretaker for my 55 year old wife who is HIV/Hep C co-infected (she suffered a hypoglycemic brain injury in 2005 and requires assistance wth her medications). She is an insulin dependent diabetic who was has been treated for HIV since 2001. Her HIV viral load and CD4 count have been good since treatment began. Now she is being treated for her Hep C, genotype 3. She is in the 18th week of Pegasys therapy, receiving 135mcg each week. The problem is that she has been plagued by a persistent hemolytic anemia that seems to be linked to Ribavirin. At the outset of therapy she was taking 800mg per day and her hgb dropped from 12 to 6.7 after acouple of weeks. Off Ribavirin, her hgb bounced back to 11.8, but has drifted down over the weeks as Ribavirin has been reinstituted.
Currently, she receives 400mg of Ribavirin QD, 135 mcg Pegasys Q week, 40,000 units procrit SC Q week, 300 mcg Neupogen Q week (ANC 400), 325 mg FeSO4 TID and a multivit. Was on Aranesp until three weeks ago, same results. Today her hgb was 8.6. She had transient cotton wool spots on her retinas a few weeks ago that appeared to be related to the low hgb. Her HIV Regimine is Isentress 400mg BID, Epivir 300mg QD, Reyataz 300 mg QD and Norvir 100mg QD. Also on Neurontin and Paxil.
I'm afraid that the anemia will sideline her HCV treatment. Is there anything we are missing?
Also, do you think that 400mg of Ribavirin along with the 135mcg Pegasys will have any chance of success given a 48 week treatment course?
I'd be grateful for your perspective.
Peter in San Diego
Response from Dr. McGovern
I am concerned that the lower dose of Ribavirin could be a problem; however, the treatment needs to be safe as well. It sounds like she is getting excellent care with all that you describe. I find that if the viral load is undetectable, then dose reduction is not as critical as when the viral load is still detectable. Then I am very hesitant to dose reduce unless I absolutely must.
Speak with your provider about her viral load results.
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