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HEPA B reactive
Dec 9, 2007

Good Day DR

My younger brother was diagnosed with HEPA B: his hepa b profile is HBsaG and HBeaG - reactive , Anti HBsaG and Anti HBeaG - non reactive

his doctor gave him a medicine (Zeffix) is this a good medicine? it is chronic hepatitis?

Response from Dr. McGovern

Zeffix is adefovir, which is a hepatitis B drug that is modestly active against HBV. I use this drug if the viral load is not too high. Resistance develops later than with the use of lamivudine and telbivudine.

Data on the use of tenofovir, its cousin, was presently recently at the liver meetings in Boston and this drug looks particularly potent. I would expect approval for this drug to hopefully occur in 2008.

Other good possible choices for the treatment of chronic hepatitis B E antigen positive infection include entecavir and pegylated interferon.

Clearing Hep-C

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