Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: TheBodyPRO.com Covers AIDS 2014
   
Ask the Experts About

Hepatitis and HIV CoinfectionHepatitis and HIV Coinfection
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


baraclude
Sep 16, 2007

Baraclude is carcinogenic on Rodent with low doses according to ASSLD. Is this a concern for patient who starts treatment with baraclude. Tyzeka and hepsera do not seem to have have this issue. What is the drug preference for treating precore mutant HBV (e-antigen negative)? Is Tyzeka better since its profile regaring carcinogen is better?

Response from Dr. McGovern

Telbivudine (Tyzeka) is not carcinogenic in mice at doses up to 14 times that used in humans.

Adefovir is not carcinogenic in mice at doses up to 10 times that used in humans.

Entecavir (Baraclude) was shown to be carcinogenic in mice - but this was at 42 times the dose that is normally given to humans! These types of studies are done all the time in the pharmaceutical industry. These data are actually reassuring.

The bottom line is that all three drugs appear to be safe in the normal doses used in humans.



Previous
Thanks from Ur Reply
Next
whats wrong with me?

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement