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Sep 16, 2007

Baraclude is carcinogenic on Rodent with low doses according to ASSLD. Is this a concern for patient who starts treatment with baraclude. Tyzeka and hepsera do not seem to have have this issue. What is the drug preference for treating precore mutant HBV (e-antigen negative)? Is Tyzeka better since its profile regaring carcinogen is better?

Response from Dr. McGovern

Telbivudine (Tyzeka) is not carcinogenic in mice at doses up to 14 times that used in humans.

Adefovir is not carcinogenic in mice at doses up to 10 times that used in humans.

Entecavir (Baraclude) was shown to be carcinogenic in mice - but this was at 42 times the dose that is normally given to humans! These types of studies are done all the time in the pharmaceutical industry. These data are actually reassuring.

The bottom line is that all three drugs appear to be safe in the normal doses used in humans.

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