HIV & HBV
Mar 23, 2007
i am doing my post graduate dissertation on HIV positive people coinfected with Hepatitis B virus and its clinical significance.i am finding normal/stable values of ALT and total Bilirubin in case of coinfected person as compared to person infected with HBV alone. is it related to suppressed immunity in case of coinfected which causes less liver damage.can you send me some links of references related to it.
Response from Dr. McGovern
Yes that is a very good question. Studies suggest that the lower aminotransferases may be related to immune suppression. This can change dramatically if a patient goes on antiretroviral therapy and their immune system improves. This can lead to "immune reconstitution" with a flare of hepatitis. I have an editorial on this in Clinical Infectious Diseases in 2004; 39:133-135.
I would suggest a PubMed search for an article on HIV/HBV coinfection by Chloe Thio as well regarding liver disease progression in Lancet.
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