Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Hepatitis and HIV CoinfectionHepatitis and HIV Coinfection
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


Isolated Hep B core: can I infect someone?
Jan 28, 2007

6 mos. ago, I tested: HBsAg: -ve; Anti-HBc (Total): +ve; Anti-HBS: -ve [I also tested -ve for HCV, HIV 1 and HIV 2 and all other STDs. ALT/AST levels were normal (14/17 if i recall right)]

Since then, I've had the following tests: HBV DNA PCR (Quantitative): undetectable at 100 copies/ml; Anti-HBc IgM: -ve; HBeAg: negative; Anti-HBe: -ve. Also confirmed the original serological pattern of the isolated Anti-HBc (Total).

I've also since taken two shots of the Hep B vaccine (and the first shot of the Hep A vaccine). I had a qual/quant anti-HBs test 1 mo. after the first 20 micro-g Hep B shot: the qual was negative, and the quant was undetectable at 5 mIU/ml.

My questions: -With a negative PCR, but no vaccine response after one shot, is there any chance i'm a low-level carrier and can infect a sexual partner? My doctor says no, but I'm sexually active and absolutely do NOT want to take any chance of infecting anyone

-What more should I do? I intend to complete the vaccination, and check the anti-HBs titers again. Also, I will repeat the HBV DNA PCR test to ensure that I'm virus-free six months after the initial test. I'm concerned that if I'm a vaccine non-responder and remain isolated Anti-HBc positive, with no other markers, is this indeterminate or can I have peace of mind? Also, should i make any modifications in diet or alcohol intake? I have excellent access to healthcare and am willing to do anything that has even a low chance of success to put my mind at ease about infectivity to partners, and health risks to myself.

Thank you for all the excellent answers on this forum.

Response from Dr. McGovern

Not having a surface antibody result after one shot does not surprise me. I would check only after three immunizations, and only in patients whom I am concerned about a poor immune response (such as an immunocompromised patient).

As for having occult hepatitis B with isolated HB core antibody. Yes it is possible, but I rarely check for this since the vast majority of the time the HBV DNA is negative. If positive, it is so low level positive, again I don't know what the clinical significance of such a test means.

Most likely, the result is a false positive. Your liver function tests are normal as well and reassuring. I would not suggest further testing.



Previous
Side effects from Interferon and Rebetol treatments
Next
HEPATITC C/ GREAT QUESTION

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement