Nov 6, 2005
I HAVE A CHRONIC HBV WITH HBVE.POSITIVE AND HIGH DNA LEVEL.WHICH MEDICATION IS VERY EFFECTIVE TO TURN THE HBVE TO NEGATIVE?THANK YOU FOR YOUR HELP
Response from Dr. McGovern
First you will need to discuss with your physician various issues such as how high your liver function tests are, since that also predicts how well you might respond to medications.
There are several medications available: Pegylated interferon alfa 2a which has the highest rates of seroconversion of E antigen from positive to negative. Entecavir, which is a new very potent anti-HBV drug. Adefovir, which is less potent but is an important drug for the treatment of resistant virus. Lamivudine or emtricitabine which are similar drugs that are effective when a patient has high liver function tests; however resistance issues are clearly a problem with these drugs.
Selection of any of the above will depend on discussions you will have with your physician, since pegylated interferon, which is given by injection, also has more side effects than the other oral drugs. Interferon is not used in patients with decompensated liver disease. Dr. M
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