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Adoption - HBcAb positive
Jul 30, 2005

We received an adoption referral for our daughter, born in China 10/3/2003. She is listed as HBcAb Positive with the rest of Hep B tests listed as Negative.

HBsAg: Negative HBsAb: Negative HBeAg: Negative HBeAb: Negative HBcAb: Positive

The narrative says that she was diagnosed with Hepatitis B (don't know at what age probably at 6 months) but with a follow up hospital visit on 2/1/05 she only had "one positive" and "originally she had 3 positives". The narrative then states "conclusion of diagnosis that Hepatitis B has disappeared".

There was also a "HBV-DNA Virus DNA flourescent quantitative" test done 3/10/05 with a result of <5.0x10^2 copy/mL.

Does this mean that the little girl had Hep B and no longer has it? What does the HBV-DNA test show? And if she is free of Hep B and only has cAb from prior infection, can we vaccinate her once she is in US?

Thank you in advance for your help.

Response from Dr. McGovern

From the blood tests we have it does appear that she was probably exposed to hepatitis B since "three tests" were positive and now she is core antibody positive. I would have thought her hepatitis surface antibody (protective antibodies) would have become positive and stayed positive too. However, she can safely receive hepatitis B vaccine when she gets to your country.

The negative surface antigen, negative e antigen and the hepatitis B DNA test are also reassuring that she does not have chronic disease and has cleared her infection.

Best of luck with your adoption proceedings. Dr. McGovern



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