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Hepatitis and HIV CoinfectionHepatitis and HIV Coinfection
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treatment goals HCV and HIV
Jan 10, 2005

Hi Doctor: Please help us understand the difference.. In HCV treatment, the goal seems to be to get HCV viremia to undetectable which is equivalent to a cure. In HIV the goal is to get viremia to undetectable, which is not a cure, but better prognosis. Why can HCV be "knocked out" and HIV not "knocked out"?

Response from Dr. Dieterich

Glad you asked! HIV is a retrovirus and immediately upon infection integrates itself into your genome, your DNA. HCV is a flavivirus, its cousins are Yellow Fever virus, Dengue Fever virus and West Nile virus, they do not integrate themselves into your DNA. When flaviviruses are gone they are really gone they were never part of your genetics but HIV and even hepatitis B integrate and are very difficult if not impossible to completely cure. Stay well! DTD

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