Thank you very much for your answer of March 31st, as a reminder here is my labs:HBSAG Positive (428) ABSAB Negative HBEAG Negative HBEAB Posiive HBCAB Total Positive IGM HBCAB Negative HCB AB Negaive HIV 1/2 Negative LFT's all Normal AFP 1.28 Normal Abdominal Ultra Sound all normal no inflamation or legions

Tests done February 15ht 2003 HBSAG Positive (528) lft normal Alt slightly raised at 41

March 28th LFT Results All normal execpt AFT raised at 52 And ALKP Raised close to 2.5 times at 273

I took your advice and took an HBVDNA by PCR test, I think it was qualitative, and now after searching on the net I think I might have taken the wrong test. What is the correct test to take to rule out precore mutant Qualitative or Quantitative?

Also in case of a precore mutant, with no evidence of cirrhosis or fibrosis on ultrasound or labs (no biopsy yet) is treatment indicated, if so which one has a better efficacy, Lamivudine, Hepsera or combo ZADAXIN and interferon alpha. Your help in this matter is very much appreciated.

HBVDNA should always be done quantitatively. I would use lamivudine and adefovir(Hepsera) for a precore mutant. DTD