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Hepatitis and HIV CoinfectionHepatitis and HIV Coinfection
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Apr 14, 2003

What cells make antibodies to Hep C? What cells make antobodies to HIV? In a co-infected person, HIV/Hep C, as disease progresses, how does HIV interact with the Hep C virus to impede antibody production and immune response? Does this activity of HIV on immune response to Hep C occur in liver only, or also in other reservoirs? Thanks.

Response from Dr. Dieterich

Lymphocytes called B cells make antibodies to any invader. Antibodies actully do not do anything to inhibit HIV or HCV. That is why the antibody test is usually a marker of infection. The only way to attack the virus is through T cells. The adverse effects of both viruses on each other probably occur through the T cell effects in the whole body. Good question! DTD

mechanism of antibody production

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