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Hep-C non-responder options
Jul 22, 2002

Hi, do you think interferon mono or combo (w/Ribavirin) maintenance is a viable option for genotype 1a non-responders? My virus count was down to 4-digits while on treatment and my liver tests were almost normal. Now since I stopped all treatment, my enzymes and virus count have all skyrocketed. thanx...Mike

Response from Dr. Fried

Maintenance therapy can be considered for those who have evidence of aggressive disease on liver biopsy, such as stage 3 or 4 fibrosis (cirrhosis). BUT, it must be remembered that there are no data that has proven that maintenance therapy will prevent long-term complications of HCV. Also, when should maintenance therapy be stopped? These questions are being addressed in current studies but the answers won't be available for a number of years. Maintenance therapy should be used very selectively, if at all.



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