Apr 28, 2002
In cases of simultaneous co-infection with several pathogens, is it known at what point viremia would present in the absence of antibodies during co-infection immunoincompetence and delayed antibody formation? Does immunoincompetence in primary infection cause viral loads to remain low/undetectable as the body is not successfully "fighting" the infection? Some scientists have postulated that in the case of HIV, the virus may actually take advantage of the mechanisms of the immune system for its replication (B cell surface to T cell nucleus), would the perturbed mechanisms of immune system itself actually keep the viremia undetectable for a long period of time? Thanks for help, Dr. Dieterich.
| Response from Dr. Dieterich
I have seen several coinfections acquired at the same time. In general two hepatitis viruses seem to cause both to be at lower levels, but not anywhere near zero. When hepatitis and HIV are acquired at the same time, there is no competition for the hepatocyte's cellular machinery, so both viruses seem to be replicating at expected levels. Antibodies may take few weeks longer, but the PCR's are positive. DTD
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