Apr 11, 2002
1- In acute HBV/HIV co-infection is HBV DNA always detectable in serum?
2-In acute HCV/HIV co-infection, is HCV RNA always detectable in serum? PCR or new TMA test better?
3-In acute HBV/HIV co-infection (with no detectable surface antigen), is development of core antibody impeded by acute co-infection immunoincompetence?
Thanks, Dr. Dieterich, for your help.
Response from Dr. Dieterich
All acute hepatitis infections will have DNA or RNA in the serum. The TMA goes down to 5 copies but is not necessary to make the diagnosis. The viral loads during acute infections are extremely high. It is possible that the core antibody can be delayed by concurrent HIV infection, but the DNA will be present. DTD
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