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Apr 8, 2002

-1 Is HBV DNA alwasy detectable in an acutely/chronically infected person? Prior to seroconversion? After seroconversion?

-2 Is HCV RNA always detectable in acutely/chronically infected person? Prior to seroconversion? After seroconversion?

Thanks for insights....


Response from Dr. Fried

If a person is positive for hepatitis B surface antigen, HBV DNA will almost always be detectable if a sensitive PCR assay is used. The level of HBV DNA is related to the degree of infectivity and the degree of disease activity.

HCV RNA will be detectable in a patient who recently bcame infected with HCV, prior to anti-HCV seroconversion. If they remain chronically infected, HCV RNA will always be detectable in the blood by a sensitive assay.

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