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Peg-Intron and Pegasys
Feb 15, 2002

What are the differences between Peg-Intron Alpha 2b and Pegasys??

Response from Dr. Rodriguez-Torres

The difference is mainly the type of Peg ,or polyethilene glycol moeity that is added to the interferon alfa.Peg Intron has a small lineal 12kd chain and Pegasys has a large ,branched ,heavy 40kd,chain.The larger molecule stays in the liver,is less distributed in the rest of the body,and the blood levels are high for more than a week. pegasys can be used in renal insufficiency,not Peg Intron.The less extrahepatic distribution of Pegasys,probably explains the more benign adverse events profile.



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