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Total Lymphocyte Count vs. CD4 Lymphocyte Count
Dec 20, 1999

Please tell me if this is correct: As HIV disease progresses the CD4 lymphocyte count decreases and the CD8 lymphocyte count increases. Because of this the total lymphocyte count (CD4 and CD8 lymphocytes together) may not decrease, but the CD4 count alone will decrease over time. Thank you for your comments!

Response from Mr. Molaghan

Hello Yes this is essentially true. As CD4+ lymphocytes become infected with HIV, the CD4 count decreases. This causes an actual or relative increase in CD8+ cells, due to the inversion of the CD4/CD8 ratio. The total lymphocyte count may or may not be decreased.

Th1 shift and HIV-related fatigue
Wondering if my fatigue is permanent.

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