Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Fatigue and AnemiaFatigue and Anemia
           
Rollover images to visit our other forums!
  
  • Email Email
  • Glossary Glossary


Just Read Your Latest Blog Entry
Apr 25, 2011

I just read your blog about the new NNRTI expected to come to market in the near future nicked-named B-tripla. By the way, I enjoyed the story. I'm not sure if that was totally real or exaggerated for entertainment purposes. In any event, it made it more interesting.

Anyway, if someone and a genotype that showed resistance to Sustiva and Viramune, would B-Tripla be out, too? I'm learning about all the meds, classes, resistance issues. I thought if someone became resistant to one NNRTI, then it would knock them all out. I would assume this would be the case with B-Tripla and any possible future NNRTI's? Sorry, I can't remember the exact name of the drug--ripla--something??

Response from Dr. Frascino

Hi,

The new drug is rilpivirine (brand name not yet established). The "B-tripla" was meant just as a funny takeoff on "Atripla," because if the FDA approves the co-formulation of rilpivirine with tenofovir and emtricitabine, the combination will be in direct competition with Atripla (efavirenz, tenofovir and emtricitabine). (See below)

The resistance profile of rilpivirine appears to suggest that it will have activity against NNRTI-resistant virus. However, the FDA may only approve it initially for naive patients. One problem with rilpivirine resistance is that it develops more rapidly than efavirenz resistance. Also, rilpivirine resistance causes cross-resistance to Intelence, which isn't the case with Atripla.

The cross-resistance you mention is most likely K103N, which can cause cross-resistance between Viramune and Sustiva. However, Intelligence (etravirine) is a "second generation" NNRTI and works in most cases when Viramune and Sustiva have failed (developed resistance). Other second generation NNRTIs are in development. Stay tuned to The Body. We'll keep you posted on promising new medications as they are developed, tested and, hopefully, approved.

Dr. Bob

http://www.thebody.com/content/art61375.html


Previous
Ways to Safely Reduce Male Sex Drive?
Next
Everyday exhaustion

  
  • Email Email
  • Glossary Glossary


 
 
Advertisement




Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement