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Lipoatrophy from Truvada and Isentress?
Apr 13, 2013

I am 47 yr old on truvada and isentress for 3 yrs or so. It seems lately arms and legs have gotten worse In the last yr. Noticeably. What are your thoughts on this? Ive been doing sculptra for a while for face. Its improved.

Response from Dr. Pierone

Hello, and thanks for posting.

Although Truvada is less likely than other nukes to produce lipoatrophy, it may still gradually develop over time. There are some studies that show better preservation of peripheral fat with protease inhibitors, but at the cost of increased cardiovascular risk. The possibility of nuke sparing and protease inhibitor sparing regimens exist, but supporting data are sparse. We have some experience with Isentress and Intelence as a regimen that might be less likely to produce lipoatrophy.

Good luck!



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